As you enter higher world tiers and unlock more difficult content, Nightmare Dungeons and Horadric Vaults become the go-to areas for advanced farming. These dungeons contain hordes of Diablo IV gold elite enemies, enhanced loot drops, and numerous chests that offer greater chances for Horadric Vials. Horadric Vaults, in particular, are densely packed with both enemies and containers, making them one of the most vial-efficient content types in the game.

Horadric Fortress
Once you begin obtaining high-tier rewards, the Horadric Fortress becomes an excellent source of potions and vials. The enemies and bosses inside scale with your power, increasing the drop rate and overall value of each run.

Chests and Seasonal Stashes
Horadric Vials can also appear randomly in world chests, seasonal caches, and stashes earned through event progression. These rewards scale with your level and world tier, so engaging with seasonal mechanics and using the Whispering Tree to speed up your level progression is recommended.

Horadric Knowledge and Focus
Fighting in Helltides, completing Nightmare Dungeons, and clearing Horadric Vaults grants Horadric Knowledge, which passively builds up as cheap Diablo IV gold you play. As your knowledge increases, you gain access to Horadric Focus, which lets you claim stashes packed with high-tier loot, including multiple Horadric Vials.

Horadric Vials are primarily used to upgrade Horadric spells, which enhance your magical abilities and give you more control over your build. However, because vials are relatively limited, especially early on, they should be used strategically.